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<tps:name>SuperscriptREF</tps:name> <tps:basedOn>*</tps:basedOn> <tps:fontSize>4.5 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> </tps:charStyleDef> </tps:definition> <tps:definition tag="charStyleDef"> <tps:charStyleDef> <tps:name>table_break</tps:name> <tps:basedOn>*</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:definition> <tps:definition tag="charStyleDef"> <tps:charStyleDef> <tps:name>TableTitle</tps:name> <tps:basedOn>*</tps:basedOn> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> <tps:color> C=15 M=100 Y=100 K=0 </tps:color> <tps:case>normal</tps:case> </tps:charStyleDef> </tps:definition> <tps:definition tag="charStyleDef"> <tps:charStyleDef> <tps:name>TB_CHAR</tps:name> <tps:basedOn>*</tps:basedOn> <tps:leading>0 pt</tps:leading> <tps:color> None </tps:color> </tps:charStyleDef> </tps:definition> <tps:definition tag="charStyleDef"> <tps:charStyleDef> <tps:name>arial</tps:name> <tps:basedOn>*</tps:basedOn> <tps:font> <tps:name>Arial</tps:name> <tps:style>Regular</tps:style> </tps:font> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:definition> <!-- =========================== --> <!-- Paragraph Style Definitions --> <!-- =========================== --> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>abstract</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>abstract</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>abstract</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>abstract2head</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>abstract2head</tps:name> <tps:font> <tps:name>OTNEJMScalaSansSmallLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>9 pt</tps:fontSize> <tps:leading>10.5 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>3.175 mm</tps:spaceBefore> <tps:nextStyle>abstract</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>abstracthead</tps:name> <tps:basedOn>head1</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>abstracthead</tps:name> <tps:basedOn>head1</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>abstracthead</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>affiliation</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>affiliation</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:spaceBefore>3.175 mm</tps:spaceBefore> <tps:spaceAfter>3.175 mm</tps:spaceAfter> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>affiliationnote</tps:name> <tps:basedOn>publishedon</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>affiliationnote</tps:name> <tps:basedOn>publishedon</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>1.76389 mm</tps:indentLeft> <tps:indentFirstLine>-1.41111 mm</tps:indentFirstLine> <tps:nextStyle>affiliationnote</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>appendixhead</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>appendixhead</tps:name> <tps:font> <tps:name>OTNEJMScalaSansSmallLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>10.5 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceBefore>6.35 mm</tps:spaceBefore> <tps:spaceAfter>0.529167 mm</tps:spaceAfter> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>appendixtext</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>appendixtext</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:indentFirstLine>2.64583 mm</tps:indentFirstLine> <tps:nextStyle>appendixtext</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>appendixtext.first</tps:name> <tps:basedOn>appendixtext</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>appendixtext.first</tps:name> <tps:basedOn>appendixtext</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentFirstLine>0 mm</tps:indentFirstLine> <tps:nextStyle>appendixtext</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>attrib</tps:name> <tps:basedOn>epigraph</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>attrib</tps:name> <tps:basedOn>epigraph</tps:basedOn> <tps:fontSize>12 pt</tps:fontSize> <tps:leading>14 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>right</tps:alignment> <tps:nextStyle>attrib</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Audio</tps:name> <tps:basedOn>affiliation</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>Audio</tps:name> <tps:basedOn>affiliation</tps:basedOn> <tps:font> <tps:name/> <tps:style>Bold</tps:style> </tps:font> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>Audio</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Audio_blue</tps:name> <tps:basedOn>Sideparagraphfirst</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>Audio_blue</tps:name> <tps:basedOn>Sideparagraphfirst</tps:basedOn> <tps:font> <tps:name/> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>9 pt</tps:fontSize> <tps:leading>11.4 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>2.11667 mm</tps:spaceBefore> <tps:nextStyle>Audio_blue</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>author</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>author</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>18 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>OpeningParagraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Banner1</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Banner1</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>33 pt</tps:fontSize> <tps:leading>29.75 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>Banner1</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Banner2</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Banner2</tps:name> <tps:font> <tps:name>OTNEJMQuadraatSmallCap</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:spaceBefore>7.05556 mm</tps:spaceBefore> <tps:nextStyle>Banner2</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>boxbody</tps:name> <tps:basedOn>boxhead</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>boxbody</tps:name> <tps:basedOn>boxhead</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>5.64444 mm</tps:indentLeft> <tps:indentFirstLine>0 mm</tps:indentFirstLine> <tps:indentRight>2.11667 mm</tps:indentRight> <tps:spaceBefore>1.41111 mm</tps:spaceBefore> <tps:nextStyle>boxbody</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>boxbodywide</tps:name> <tps:basedOn>boxbody</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>boxbodywide</tps:name> <tps:basedOn>boxbody</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>0 mm</tps:indentLeft> <tps:indentRight>0 mm</tps:indentRight> <tps:nextStyle>boxbodywide</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>boxfootnote</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>boxfootnote</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>3.175 mm</tps:indentLeft> <tps:indentRight>0 mm</tps:indentRight> <tps:spaceBefore>2.11667 mm</tps:spaceBefore> <tps:nextStyle>boxfootnote</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>boxhead</tps:name> <tps:basedOn>tablehead</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>boxhead</tps:name> <tps:basedOn>tablehead</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left</tps:alignment> <tps:indentLeft>2.11667 mm</tps:indentLeft> <tps:spaceBefore>1.76389 mm</tps:spaceBefore> <tps:nextStyle>boxhead</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>boxtitle</tps:name> <tps:basedOn>tabletitle</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>boxtitle</tps:name> <tps:basedOn>tabletitle</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>boxtitle</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Copyright9</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Copyright9</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Italic</tps:style> </tps:font> <tps:fontSize>6 pt</tps:fontSize> <tps:leading>7 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:spaceBefore>0.705556 mm</tps:spaceBefore> <tps:nextStyle>Copyright9</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Copyright12</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Copyright12</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Italic</tps:style> </tps:font> <tps:fontSize>6 pt</tps:fontSize> <tps:leading>7 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:spaceBefore>0.705556 mm</tps:spaceBefore> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Date</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Date</tps:name> <tps:font> <tps:name>OTNEJMScalaSansSmallLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>12.6 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> <tps:color> C=0 M=100 Y=100 K=0 </tps:color> </tps:charStyleDef> </tps:charStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>disclosure</tps:name> <tps:basedOn>supportedby</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>disclosure</tps:name> <tps:basedOn>supportedby</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>0.705556 mm</tps:spaceBefore> <tps:nextStyle>disclosure</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>DOI</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>DOI</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>7 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> <tps:color> Black65 </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:spaceBefore>2.11667 mm</tps:spaceBefore> <tps:nextStyle>DOI</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Drop2</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Drop2</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>editor</tps:name> <tps:basedOn>author</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>editor</tps:name> <tps:basedOn>author</tps:basedOn> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> <tps:color> Black </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>0 mm</tps:spaceBefore> <tps:nextStyle>editor</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>endnote text</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>endnote text</tps:name> <tps:font/> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>endnote text</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>epigraph</tps:name> <tps:basedOn>OpeningParagraph</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>epigraph</tps:name> <tps:basedOn>OpeningParagraph</tps:basedOn> <tps:fontSize>13.4 pt</tps:fontSize> <tps:leading>16 pt</tps:leading> <tps:color> C=0 M=0 Y=0 K=50 </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>epigraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Extract</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Extract</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:indentLeft>4.23333 mm</tps:indentLeft> <tps:indentRight>4.23333 mm</tps:indentRight> <tps:spaceBefore>4.23333 mm</tps:spaceBefore> <tps:spaceAfter>4.23333 mm</tps:spaceAfter> <tps:nextStyle>paragraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>figurelegend</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>figurelegend</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:spaceBefore>0.705556 mm</tps:spaceBefore> <tps:nextStyle>figurelegend</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>figuretitle</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>figuretitle</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>figurelegend</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Folio</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Folio</tps:name> <tps:font> <tps:name>OTNEJMQuadraatCap</tps:name> <tps:style/> </tps:font> <tps:fontSize>9.5 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>Folio</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>footer</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>footer</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLFCap</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.25 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>footer</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head1</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>head1</tps:name> <tps:font> <tps:name>OTNEJMQuadraatSmallCap</tps:name> <tps:style/> </tps:font> <tps:fontSize>10.5 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceBefore>5.64444 mm</tps:spaceBefore> <tps:spaceAfter>3.52778 mm</tps:spaceAfter> <tps:nextStyle>paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head1_2line</tps:name> <tps:basedOn>head1</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>head1_2line</tps:name> <tps:basedOn>head1</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head1_3line</tps:name> <tps:basedOn>head1</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>head1_3line</tps:name> <tps:basedOn>head1</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>head1_3line</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head2</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>head2</tps:name> <tps:font> <tps:name>OTNEJMScalaSansSmallLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>9 pt</tps:fontSize> <tps:leading>10.5 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>4.40972 mm</tps:spaceBefore> <tps:nextStyle>paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head2_2line</tps:name> <tps:basedOn>head2</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>head2_2line</tps:name> <tps:basedOn>head2</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head2_2line.after</tps:name> <tps:basedOn>head2_2line</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>head2_2line.after</tps:name> <tps:basedOn>head2_2line</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>0.176389 mm</tps:spaceBefore> <tps:nextStyle>paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head2.after</tps:name> <tps:basedOn>head2</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>head2.after</tps:name> <tps:basedOn>head2</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>0.176389 mm</tps:spaceBefore> <tps:nextStyle>paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head3</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>head3</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Italic</tps:style> </tps:font> <tps:fontSize>9.5 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>4.23333 mm</tps:spaceBefore> <tps:nextStyle>paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head4</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>head4</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>9.5 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> <tps:color> Black </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:indentFirstLine>3.52778 mm</tps:indentFirstLine> <tps:nextStyle>head4</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>indebtedto</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>indebtedto</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:indentFirstLine>2.82222 mm</tps:indentFirstLine> <tps:nextStyle>indebtedto</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>kcp_caption</tps:name> <tps:basedOn>head2</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>kcp_caption</tps:name> <tps:basedOn>head2</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>2.11667 mm</tps:spaceBefore> <tps:spaceAfter>1.05833 mm</tps:spaceAfter> <tps:nextStyle>kcp_item</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>kcp_item</tps:name> <tps:basedOn>tablebody_0-12</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>kcp_item</tps:name> <tps:basedOn>tablebody_0-12</tps:basedOn> <tps:fontSize>8.5 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>kcp_item</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>kcp_label</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>kcp_label</tps:name> <tps:font> <tps:name>OTNEJMScalaSansSmallLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>10.5 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceBefore>1.05833 mm</tps:spaceBefore> <tps:spaceAfter>0.352778 mm</tps:spaceAfter> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>OpeningParagraph</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>OpeningParagraph</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>13.4 pt</tps:fontSize> <tps:leading>16 pt</tps:leading> <tps:color> C=0 M=0 Y=0 K=50 </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:spaceAfter>1.05833 mm</tps:spaceAfter> <tps:nextStyle>paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>paragraph</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>paragraph</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:indentFirstLine>4.23333 mm</tps:indentFirstLine> <tps:nextStyle>paragraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Paragraph Style 1</tps:name> <tps:basedOn>tabletitle</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>Paragraph Style 1</tps:name> <tps:basedOn>tabletitle</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>Paragraph Style 1</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>paragraph.drop2</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>paragraph.drop2</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>paragraph.drop3</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>paragraph.drop3</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>paragraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>paragraph.first</tps:name> <tps:basedOn>paragraph</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>paragraph.first</tps:name> <tps:basedOn>paragraph</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentFirstLine>0 mm</tps:indentFirstLine> <tps:nextStyle>paragraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>paragraphfirst</tps:name> <tps:basedOn>paragraph</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>paragraphfirst</tps:name> <tps:basedOn>paragraph</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>paragraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>prod.note</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>prod.note</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>prod.note</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>publishedon</tps:name> <tps:basedOn>affiliation</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>publishedon</tps:name> <tps:basedOn>affiliation</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>2.11667 mm</tps:spaceBefore> <tps:nextStyle>publishedon</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>PullQuote</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>PullQuote</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold Italic</tps:style> </tps:font> <tps:fontSize>14.5 pt</tps:fontSize> <tps:leading>20 pt</tps:leading> <tps:color> C=50 M=95 Y=22 K=37 </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>PullQuote</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>referencefirst</tps:name> <tps:basedOn>references</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>referencefirst</tps:name> <tps:basedOn>references</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>referencefirst</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>references</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>references</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:nextStyle>references</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>references.balancer</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>references.balancer</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>0.1 pt</tps:fontSize> <tps:leading>0 pt</tps:leading> <tps:color> C=0 M=100 Y=0 K=0 </tps:color> </tps:charStyleDef> </tps:charStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>referenceshead</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>referenceshead</tps:name> <tps:font> <tps:name>OTNEJMScalaSansSmallLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>10.5 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>6.35 mm</tps:spaceBefore> <tps:spaceAfter>0.529167 mm</tps:spaceAfter> <tps:nextStyle>references</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Related Article</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Related Article</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> <tps:color> 65% Black </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>right</tps:alignment> <tps:nextStyle>Related Article</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>response</tps:name> <tps:basedOn>paragraph</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>response</tps:name> <tps:basedOn>paragraph</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>response</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>response.first</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>response.first</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>4.23333 mm</tps:spaceBefore> <tps:nextStyle>response.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>runninghd</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>runninghd</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLFSmallCap</tps:name> <tps:style/> </tps:font> <tps:fontSize>8.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>right</tps:alignment> <tps:nextStyle>runninghd</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>runninghdL</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>runninghdL</tps:name> <tps:font> <tps:name>OTNEJMQuadraatCap</tps:name> <tps:style/> </tps:font> <tps:fontSize>9 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>runninghead.invisible</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>runninghead.invisible</tps:name> <tps:font> <tps:name>OTNEJMScalaSansSmallLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>0.1 pt</tps:fontSize> <tps:leading>0 pt</tps:leading> <tps:color> Paper </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>runninghead.invisible</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>SectionTitleFront</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>SectionTitleFront</tps:name> <tps:font> <tps:name>OTNEJMQuadraatSmallCap</tps:name> <tps:style/> </tps:font> <tps:leading>13 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>title</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>series-title</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>series-title</tps:name> <tps:font> <tps:name>OTNEJMScalaSansSmallLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>9 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>series-title</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>series-title.rule</tps:name> <tps:basedOn>series-title</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>series-title.rule</tps:name> <tps:basedOn>series-title</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>6.35 mm</tps:spaceBefore> <tps:nextStyle>series-title.rule</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>SideAuthor</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>SideAuthor</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>9 pt</tps:fontSize> <tps:leading>21 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>SideDrop2</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>SideDrop2</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>SideDrop2</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>13 pt</tps:leading> <tps:color> Slug </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:nextStyle>SideDrop2</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Sideparagraph</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Sideparagraph</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>13 pt</tps:leading> <tps:color tint="100 %"> Slug </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:indentFirstLine>4.23333 mm</tps:indentFirstLine> <tps:nextStyle>Sideparagraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Sideparagraphfirst</tps:name> <tps:basedOn>paragraphfirst</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>Sideparagraphfirst</tps:name> <tps:basedOn>paragraphfirst</tps:basedOn> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:leading>0 pt</tps:leading> <tps:color> Slug </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>Sideparagraphfirst</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>SideTitle</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>SideTitle</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>18 pt</tps:fontSize> <tps:leading>20 pt</tps:leading> <tps:color> Slug </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>SideTitle</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Slug</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Slug</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>9 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> <tps:color> Slug </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:nextStyle>Slug</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>src</tps:name> <tps:basedOn>figurelegend</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>src</tps:name> <tps:basedOn>figurelegend</tps:basedOn> <tps:fontSize>6 pt</tps:fontSize> <tps:leading>8 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>src</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>stage</tps:name> <tps:basedOn>response</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>stage</tps:name> <tps:basedOn>response</tps:basedOn> <tps:font> <tps:name/> <tps:style>Bold</tps:style> </tps:font> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>stage.first</tps:name> <tps:basedOn>response.first</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>stage.first</tps:name> <tps:basedOn>response.first</tps:basedOn> <tps:font> <tps:name/> <tps:style>Bold</tps:style> </tps:font> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>stage</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Subtitle</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Subtitle</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>13.5 pt</tps:fontSize> <tps:leading>15.5 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceBefore>1.41111 mm</tps:spaceBefore> <tps:nextStyle>Subtitle</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>supportedby</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>supportedby</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:indentFirstLine>2.82222 mm</tps:indentFirstLine> <tps:nextStyle>indebtedto</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>table.FPO</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>table.FPO</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>table.FPO</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tableanchor</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tableanchor</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>3.35139 mm</tps:indentLeft> <tps:indentFirstLine>-1.23472 mm</tps:indentFirstLine> <tps:indentRight>2.11667 mm</tps:indentRight> <tps:nextStyle>tablefootnote</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>tablebody</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_0-12</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_0-12</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>4.23333 mm</tps:indentLeft> <tps:indentFirstLine>-4.23333 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_0-12</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_0-24</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_0-24</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>8.46667 mm</tps:indentLeft> <tps:indentFirstLine>-8.46667 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_0-24</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_0-36</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_0-36</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>12.7 mm</tps:indentLeft> <tps:indentFirstLine>-12.7 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_0-36</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_0-48</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_0-48</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>16.9333 mm</tps:indentLeft> <tps:indentFirstLine>-16.9333 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_0-48</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_12-24</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_12-24</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>8.46667 mm</tps:indentLeft> <tps:indentFirstLine>-4.23333 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_12-24</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_12-36</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_12-36</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>12.7 mm</tps:indentLeft> <tps:indentFirstLine>-8.46667 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_12-36</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_12-48</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_12-48</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>16.9333 mm</tps:indentLeft> <tps:indentFirstLine>-12.7 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_12-48</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_24-36</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_24-36</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>12.7 mm</tps:indentLeft> <tps:indentFirstLine>-4.23333 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_24-36</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_24-48</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_24-48</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>16.9333 mm</tps:indentLeft> <tps:indentFirstLine>-8.46667 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_24-48</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_36-48</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_36-48</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>16.9333 mm</tps:indentLeft> <tps:indentFirstLine>-4.23333 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_36-48</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody-12</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody-12</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>8.46667 mm</tps:indentLeft> <tps:nextStyle>tablebody-12</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody-24</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody-24</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>12.7 mm</tps:indentLeft> <tps:nextStyle>tablebody-24</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody-36</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody-36</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>16.9333 mm</tps:indentLeft> <tps:nextStyle>tablebody-36</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody-char</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody-char</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>tablebody-char</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody.head</tps:name> <tps:basedOn>tablebody.paragraph.first</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody.head</tps:name> <tps:basedOn>tablebody.paragraph.first</tps:basedOn> <tps:font> <tps:name/> <tps:style>Bold</tps:style> </tps:font> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>1.05833 mm</tps:spaceBefore> <tps:nextStyle>tablebody.head</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody.paragraph</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody.paragraph</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentFirstLine>4.23333 mm</tps:indentFirstLine> <tps:nextStyle>tablebody.paragraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody.paragraph.first</tps:name> <tps:basedOn>tablebody.paragraph</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody.paragraph.first</tps:name> <tps:basedOn>tablebody.paragraph</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentFirstLine>0 mm</tps:indentFirstLine> <tps:nextStyle>tablebody.paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebodyctr</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebodyctr</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>tablebodyctr</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebodydec</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebodydec</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:nextStyle>tablebodydec</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablefootnote</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablefootnote</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>2.11667 mm</tps:indentLeft> <tps:indentFirstLine>-2.11667 mm</tps:indentFirstLine> <tps:nextStyle>tablefootnote</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablefootnote.double</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablefootnote.double</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>4.23333 mm</tps:indentLeft> <tps:indentFirstLine>-4.23333 mm</tps:indentFirstLine> <tps:nextStyle>tablefootnote.double</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablefootnote.first</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablefootnote.first</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>0.529167 mm</tps:spaceBefore> <tps:nextStyle>tablefootnote</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablefootnote.first.double</tps:name> <tps:basedOn>tablefootnote.first</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablefootnote.first.double</tps:name> <tps:basedOn>tablefootnote.first</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>4.58611 mm</tps:indentLeft> <tps:indentFirstLine>-4.23333 mm</tps:indentFirstLine> <tps:nextStyle>tablefootnote.first.double</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablefootnote.first.triple</tps:name> <tps:basedOn>tablefootnote.first.double</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablefootnote.first.triple</tps:name> <tps:basedOn>tablefootnote.first.double</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>6.35 mm</tps:indentLeft> <tps:indentFirstLine>-6.35 mm</tps:indentFirstLine> <tps:nextStyle>tablefootnote.first.triple</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablefootnote.spacer</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablefootnote.spacer</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:fontSize>4.5 pt</tps:fontSize> <tps:leading>4.5 pt</tps:leading> <tps:color> None </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>tablefootnote.spacer</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablefootnote.triple</tps:name> <tps:basedOn>tablefootnote.double</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablefootnote.triple</tps:name> <tps:basedOn>tablefootnote.double</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>6.35 mm</tps:indentLeft> <tps:indentFirstLine>-6.35 mm</tps:indentFirstLine> <tps:nextStyle>tablefootnote.triple</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablefootnotefirst</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablefootnotefirst</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>2.11667 mm</tps:spaceBefore> <tps:nextStyle>tablefootnote</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablefootnotelast</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablefootnotelast</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>tablefootnotelast</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablehead</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablehead</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>tablehead</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tableheadA</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tableheadA</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>tableheadA</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tableheadB</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tableheadB</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>tableheadB</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tableheadC</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tableheadC</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Italic</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>tableheadC</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tabletitle</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tabletitle</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> <tps:color> White </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:indentRight>2.11667 mm</tps:indentRight> <tps:spaceAfter>2.29306 mm</tps:spaceAfter> <tps:nextStyle>tabletitle</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>title</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>title</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>18 pt</tps:fontSize> <tps:leading>20 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>author</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>title.other</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>title.other</tps:name> <tps:font/> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>title.other</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>title.subsequent</tps:name> <tps:basedOn>title</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>title.subsequent</tps:name> <tps:basedOn>title</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>6.35 mm</tps:spaceBefore> <tps:nextStyle>title.subsequent</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Web Call Out 1</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Web Call Out 1</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>11 pt</tps:leading> <tps:color> NEJM Red </tps:color> <tps:case>all</tps:case> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>Web Call Out 1</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>webcallout</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>webcallout</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold Italic</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9.5 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>webcallout</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>webcallout.graphic</tps:name> <tps:basedOn>webcallout</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>webcallout.graphic</tps:name> <tps:basedOn>webcallout</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>webcallout.graphic</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>persp.tabletitle</tps:name> <tps:basedOn>tabletitle</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>persp.tabletitle</tps:name> <tps:basedOn>tabletitle</tps:basedOn> <tps:leading>0 pt</tps:leading> <tps:color> White </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:indentRight>2.11667 mm</tps:indentRight> <tps:nextStyle>persp.tabletitle</tps:nextStyle> </tps:parStyleDef> </tps:definition> <!-- ======================= --> <!-- Table Style Definitions --> <!-- ======================= --> <tps:definition tag="tableStyleDef"> <tps:tableStyleDef> <tps:name>Standard</tps:name> </tps:tableStyleDef> </tps:definition> <!-- ================================== --> <!-- Cross-reference Format Definitions --> <!-- ================================== --> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Full Paragraph &amp; Page Number</tps:name> </tps:crossRefFormatDef> </tps:definition> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Full Paragraph</tps:name> </tps:crossRefFormatDef> </tps:definition> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Paragraph Text &amp; Page Number</tps:name> </tps:crossRefFormatDef> </tps:definition> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Paragraph Text</tps:name> </tps:crossRefFormatDef> </tps:definition> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Paragraph Number &amp; Page Number</tps:name> </tps:crossRefFormatDef> </tps:definition> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Paragraph Number</tps:name> </tps:crossRefFormatDef> </tps:definition> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Text Anchor Name &amp; Page Number</tps:name> </tps:crossRefFormatDef> </tps:definition> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Text Anchor Name</tps:name> </tps:crossRefFormatDef> </tps:definition> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Page Number</tps:name> </tps:crossRefFormatDef> </tps:definition> <!-- ======================= --> <!-- Master Page Definitions --> <!-- ======================= --> <tps:definition tag="masterSpreadDef"> <tps:masterSpreadDef> <tps:name>A-Master</tps:name> <tps:pageInfo classifier="0"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="10.9361 mm" right="21.8722 mm" bottom="27.8694 mm"/> <tps:frames> <tps:frame type="mainStoryFrame"/> </tps:frames> </tps:pageInfo> <tps:pageInfo classifier="1"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="21.8722 mm" right="10.9361 mm" bottom="27.8694 mm"/> <tps:frames> <tps:frame type="mainStoryFrame"/> </tps:frames> </tps:pageInfo> </tps:masterSpreadDef> </tps:definition> <tps:definition tag="masterSpreadDef"> <tps:masterSpreadDef> <tps:name>C-Opener</tps:name> <tps:pageInfo classifier="0"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="21.8722 mm" right="10.9361 mm" bottom="27.8694 mm"/> <tps:frames> <tps:frame type="mainStoryFrame"/> <tps:frame name="alt-title" type="element"> <tps:frame type="contentFrame"/> </tps:frame> <tps:frame name="article-title" type="element"> <tps:frame type="contentFrame"/> </tps:frame> </tps:frames> </tps:pageInfo> </tps:masterSpreadDef> </tps:definition> <tps:definition tag="masterSpreadDef"> <tps:masterSpreadDef> <tps:name>Z-Figure_port</tps:name> <tps:pageInfo classifier="0"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="35.2778 mm" right="21.8722 mm" bottom="27.8694 mm"/> </tps:pageInfo> <tps:pageInfo classifier="1"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="21.8722 mm" right="35.2778 mm" bottom="27.8694 mm"/> </tps:pageInfo> </tps:masterSpreadDef> </tps:definition> <tps:definition tag="masterSpreadDef"> <tps:masterSpreadDef> <tps:name>Z-Table_port</tps:name> <tps:pageInfo classifier="0"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="35.2778 mm" right="21.8722 mm" bottom="27.8694 mm"/> </tps:pageInfo> <tps:pageInfo classifier="1"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="21.8722 mm" right="35.2778 mm" bottom="27.8694 mm"/> <tps:frames> <tps:frame type="mainStoryFrame"/> </tps:frames> </tps:pageInfo> </tps:masterSpreadDef> </tps:definition> <tps:definition tag="masterSpreadDef"> <tps:masterSpreadDef> <tps:name>Z-Boxes</tps:name> <tps:pageInfo classifier="0"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="21.8722 mm" right="35.2778 mm" bottom="27.8694 mm"/> <tps:frames> <tps:frame name="box-title" type="element"> <tps:frame type="contentFrame"/> </tps:frame> <tps:frame name="box-title" type="element"> <tps:frame type="contentFrame"/> </tps:frame> <tps:frame name="box-title" type="element"> <tps:frame type="contentFrame"/> </tps:frame> <tps:frame name="box-title" type="element"> <tps:frame type="contentFrame"/> </tps:frame> </tps:frames> </tps:pageInfo> </tps:masterSpreadDef> </tps:definition> <tps:definition tag="masterSpreadDef"> <tps:masterSpreadDef> <tps:name>Z-Typefitter Pro</tps:name> <tps:pageInfo classifier="0"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="35.2778 mm" right="21.8722 mm" bottom="27.8694 mm"/> </tps:pageInfo> <tps:pageInfo classifier="1"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="21.8722 mm" right="35.2778 mm" bottom="27.8694 mm"/> </tps:pageInfo> </tps:masterSpreadDef> </tps:definition> <tps:definition tag="masterSpreadDef"> <tps:masterSpreadDef> <tps:name>B-Table_land</tps:name> <tps:pageInfo classifier="0"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="35.2778 mm" right="21.8722 mm" bottom="27.8694 mm"/> <tps:frames> <tps:frame name="table-title" type="element"> <tps:frame type="contentFrame"/> </tps:frame> </tps:frames> </tps:pageInfo> <tps:pageInfo classifier="1"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="21.8722 mm" right="35.2778 mm" bottom="27.8694 mm"/> </tps:pageInfo> </tps:masterSpreadDef> </tps:definition> <tps:definition tag="masterSpreadDef"> <tps:masterSpreadDef> <tps:name>Z-InteractiveNote</tps:name> <tps:pageInfo classifier="0"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="10.9361 mm" right="21.8722 mm" bottom="27.8694 mm"/> <tps:frames> <tps:frame type="mainStoryFrame"/> <tps:frame type="mainStoryFrame"/> </tps:frames> </tps:pageInfo> <tps:pageInfo classifier="1"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="21.8722 mm" right="10.9361 mm" bottom="27.8694 mm"/> <tps:frames> <tps:frame type="mainStoryFrame"/> <tps:frame type="mainStoryFrame"/> </tps:frames> </tps:pageInfo> </tps:masterSpreadDef> </tps:definition> <!-- ============================================= --> <!-- Template Item Definitions (Main Story Frames) --> <!-- ============================================= --> <tps:definition tag="templateItemDef"> <tps:templateItemDef type="mainStoryFrame"> <tps:name>A-Master:0</tps:name> <tps:partOf> <tps:masterPage> <tps:spreadName>A-Master</tps:spreadName> <tps:spreadSide>0</tps:spreadSide> </tps:masterPage> </tps:partOf> <tps:pos x="25.0472 mm" y="19.05 mm"/> <tps:size width="153.106 mm" height="218.017 mm"/> <tps:autoText> <tps:leading>0 pt</tps:leading> <tps:parStyle/> <tps:baselineToFrameGap>0 mm</tps:baselineToFrameGap> </tps:autoText> <tps:rules/> </tps:templateItemDef> </tps:definition> <tps:definition tag="templateItemDef"> <tps:templateItemDef type="mainStoryFrame"> <tps:name>A-Master:1</tps:name> <tps:partOf> <tps:masterPage> <tps:spreadName>A-Master</tps:spreadName> <tps:spreadSide>1</tps:spreadSide> </tps:masterPage> </tps:partOf> <tps:pos x="35.9481 mm" y="19.05 mm"/> <tps:size width="153.106 mm" height="218.017 mm"/> <tps:autoText> <tps:leading>0 pt</tps:leading> <tps:parStyle/> <tps:baselineToFrameGap>0 mm</tps:baselineToFrameGap> </tps:autoText> <tps:rules/> </tps:templateItemDef> </tps:definition> <tps:definition tag="templateItemDef"> <tps:templateItemDef type="mainStoryFrame"> 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